Foundation & Context
Introduction, 3,000 years of psoriasis history, and global epidemiology.
Psoriasis: The Missing Manual
A comprehensive, evidence-based guide to psoriasis, covering immunology, genetics, comorbidities, and treatment. Compiled from 230+ peer-reviewed sources.
Understanding the Disease
Immune system primer, genetics, immunopathogenesis, novel mechanisms, environmental triggers, and drug-induced psoriasis.
Clinical Recognition & Diagnosis
Clinical presentation, difficult-to-treat sites, diagnostic testing, and biomarkers.
Psoriasis as a Systemic Disease
Comorbidities, psoriatic arthritis, psychological burden, sleep, sexual health, pain, and itch.
Living with Psoriasis
Evidence-based lifestyle and diet advice, daily management, and special populations.
Treatment
Remission, topical treatments, the biologic revolution, NHS pathway, and traditional medicine.
Recent Advances & Future Directions
Landmark studies, emerging therapies, digital health, and vaccination.
About This Book
Author: Miko Pawlikowski Date: February 2026
I’m not a doctor. I’m a software engineer with psoriasis who wanted a single, rigorous guide to the science behind the disease. This book synthesises the current state of psoriasis research into something comprehensive and honest. Every claim is cited, every mechanism explained. It’s free to read at psoriasis.fyi.